Cyclic exposure to hypoxia and reoxygenation selects for tumor cells Biology Diagrams The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role …
The expression of genes regulating the response to hypoxia—Hif1a, Epas1, Hif3a, and Vegf—inflammation—Nfkb, Il1b, Il6, Tnfa, Il10, and Tgfb—and the cell cycle and apoptosis—Trp53, Pten, Cmet, Egf, Egfr, Pcna, Mki67, and Bax, Bcl2—as well as genes encoding the epithelial barrier components—Muc1, Muc13, Cldn2, and Cldn7—in the
Role of Hypoxia in the Control of the Cell Cycle Biology Diagrams
HIFs bind to hypoxia response elements (HREs) in the promoter regions of a large number of targets, including those involved in cell survival, angiogenesis, glycolysis, and invasion/metastasis. Certain mutations in TSC2 confer a growth advantage to cells by repressing hypoxic mTORC1 inhibition and hypoxia-induced cell cycle arrest 135.
The transcriptional response to hypoxia and the role of hypoxia inducible factors have been extensively studied. Yet, hypoxic cells also adapt to hypoxia by modulating protein synthesis In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division. Keywords: hypoxia, cell cycle, HIF, PHDs, 2-OGDs
Responding to Hypoxia: Lessons From a Model Cell Line Biology Diagrams
The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with
